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trial #
trial description
  • Alliance N1048
  • The standard treatment for locally advanced rectal cancer involves the use of the chemotherapy drugs 5-fluorouracil and capecitabine plus radiation therapy prior to surgery. Although radiation therapy to the pelvis has been a standard and an important part of treatment for rectal cancer and has been shown to decrease the risk of the cancer coming back in the same area in the pelvis, some patients experience undesirable side effects from the radiation and there have been important advances in chemotherapy, surgery, and radiation which may be of benefit. The purpose of this study is to compare the effects, both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy using a combination regimen known as FOLFOX, (the drugs 5-fluorouracil, oxaliplatin, and leucovorin) and selective use of the standard treatment, depending on response to the FOLFOX.

  • CTSU EA2142
  • The purpose of this study is to compare the effects, both good and bad, of the study drugs temozolomide and capecitabine to the usual chemotherapy treatment for this disease of cisplatin and etoposide. Usually the first treatment given for this cancer is cisplatin and etoposide. The chemotherapy drugs temozolomide and capecitabine are also used to treat this disease but usually not until the first treatment, cisplatin and etoposide, stops working. It is not known if this is the best approach or if the temozolomide and capecitabine should be given first instead. The use of temozolomide and capecitabine could shrink your cancer but it could also cause side effects.

  • The main purpose of this international, multicenter study is to establish the standard of care for advanced or metastatic anal cancer. Unfortunately, due to the fact that anal cancer is a relatively rare disease there is currently no nationally and internationally agreed standard chemotherapy treatment. At present, the most frequently prescribed chemotherapy is a combination of two drugs called cisplatin and 5-fluorouracil. However, a formal comparison of this combination with other chemotherapies (potentially more effective, or equally effective but potentially less toxic) has never been performed.  

  • NRG GI001
  • There are two usual approaches for treating liver cancer, chemotherapy (gemcitabine and cisplatin) or radiation therapy. The purpose of this study is to compare any good and bad side effects of using the combination of gemcitabine and cisplatin (the usual approach) with the combination of gemcitabine and cisplatin followed by radiation therapy to find out which is better.


  • NRG GI002
  • NRG GI003
  • SWOG S0820
  • The purpose of this study is to determine if eflornithine and sulindac, taken alone or in combination, can decrease the risk of high-risk adenomas or second primary colorectal cancers in patients who have been treated for Stage 0, I, II or III colon cancer.